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毕蕊，女，博士，正高级工程师。从事阿尔茨海默?。ˋD）等疾病的遗传机制研究和动物模型构建，致力于通过精原干细胞途径对类灵长类动物树鼩和非人灵长类动物（猕猴、食蟹猴）进行精准基因编辑，建立疾病动物模型。以第一作者或通讯作者（含共同）在Nucleic Acids Research、Biological Psychiatry、Innovation、American Journal of Human Genetics等期刊发表SCI论文23篇。主持国家自然科学基金青年项目和面上项目，云南省基础研究计划面上项目和重点项目。入选云南省兴滇英才计划、中国科学院青年创新促进会、中国科学院“西部之光”青年学者和中国科学院“十四五”院级特聘骨干。

学习和工作经历

2025. 08- 至今 中国科学院昆明动物研究所，正高级工程师

2018. 01- ?2025.07? 中国科学院昆明动物研究所，副研究员

2015. 01- 2017.12? 中国科学院昆明动物研究所，助理研究员

2009.09 - 2014.12?? 中国科学院昆明动物研究所，遗传学，理学博士

2005.09 - 2009.06?? 云南大学，生物技术基地班，学士

近5年内发表的代表性论文/专著：?

(1)?Bi R^#, Pan L-N^#, Dai H^#, Sun C^#, Li C^#, Lin H-J, Xie L-P, Ma H-X, Li L, Xie H, Guo K, Hou C-H, Yao Y-G*, Chen L-N*, Zheng P*. Epigenetic characterization of adult rhesus monkey spermatogonial stem cells identifies key regulators of stem cell homeostasis. Nucleic Acids Research, 2024, 52(22):13644-13664.

(2)?Li H^#, Xiang B-L^#, Li X, Li C, Li Y, Miao Y, Ma G-L, Ma Y-H, Chen J-Q, Zhang Q-Y, Lv L-B, Zheng P, Bi R*, Yao Y-G*. Cognitive deficits and Alzheimer’s disease-like pathologies in the aged Chinese tree shrew. Molecular Neurobiology, 2024, 61(4):1892-1906.

(3)?Xu M^#, Liu Q^#, Bi R^#, Li Y, Li H, Kang W-B, Yan Z, Zheng Q, Sun C, Ye M, Xiang B-L, Luo X-J, Li M, Zhang D-F*, Yao Y-G*. Coexistence of Multiple Functional Variants and Genes Underlies Genetic Risk Locus 11p11.2 of Alzheimer's Disease. Biological Psychiatry, 2023, 94(9):743-759.

(4) Li Y^#, Xu M^#, Xiang B-L, Li X, Zhang D-F, Zhao H, Bi R*, Yao Y-G*. Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer's disease. Neuropsychopharmacology, 2023, 48(11), 1555–1566.

(5)?Bi R*^,#, Li Y^#, Xu M^#, Zheng Q, Zhang DF, Li X, Ma G, Xiang B, Zhu X, Zhao H, Huang X, Zheng P, Yao YG*. Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing.The Innovation, 2022, 3: 100329.

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其他代表性论文/专著: ?

(1)?Guo H, Guo L, Yuan Y, Liang XY, Bi R*. Co-occurrence of m.15992A>G and m.15077G>A Is Associated With a High Penetrance of Maternally Inherited Hypertension in a Chinese Pedigree, Am J Hypertens, 2022, 35(1):96-102.

(2)?Zheng Q^#, Bi R^#, Xu M, Zhang D-F, Tan L-W, Lu Y-P, Yao Y-G*. Exploring the genetic association of the ABAT gene with Alzheimer's disease, Mol Neurobiol, 2021, 58(5):1894-1903

(3)?Bi R*, Zhang W, Zhang D-F, Xu M, Fan Y, Hu Q-X, Jiang H-Y, Tan L, Li T, Fang Y, Zhang C, Yao Y-G*. Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese. Neuropsychopharmacology, 2018, 43: 2264 - 2276.

(4)?Wang D^#, Fan Y^#, Malhi M^#, Bi R^#, Wu Y, Xu M, Yu X-F, Long H, Li Y-Y, Zhang D-F*, Yao Y-G*. Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese, ?Am J Hum Genet, 2018, 102: 794 – 805.

(5)?Bi R^#, Kong L-L^#, Xu M, Li G-D, Zhang D-F, Alzheimer’s Disease Neuroimaging Initiative, Li T, Fang Y, Zhang C, Zhang B, Yao Y-G*. The Arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese, Mol Neurobiol, 2018, 55: 1217-1226.

(6)?Xiang Q, Bi R*, Xu M, Zhang D-F, Tan L, Zhang C, Fang Y, Yao Y-G*. Rare genetic variants of the transthyretin gene are associated with Alzheimer’s disease in Han Chinese, Mol Neurobiol, 2017, 54: 5192-5200.

(7) Li H^#, Bi R^#, Fan Y, Wu Y, Tang Y, Li Z, He Y, Zhou J, Tang J*, Chen X*, Yao Y-G*. mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia, Mol Neurobiol, 2017, 54: 4343-4352.

(8)?Guo L, Yuan Y, Bi R*. Mitochondrial DNA mutation m.5512A > G in the acceptor-stem of mitochondrial tRNATrp causing maternally inherited essential hypertension, Biochem Biophys Res Commun, 2016, 479: 800-807.

(9)?Bi R, Tang J, Zhang W, Li X, Chen SY, Yu D, Chen X, Yao YG*. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia, Schizophr Res, 2016, 171(1-3):200-206.

(10) Wang HZ^#, Bi R^#, Hu QX, Xiang Q, Zhang C, Zhang DF, Zhang W, Ma X, Guo W, Deng W, Zhao L, Ni P, Li M, Fang Y, Li T, Yao YG*. Validating GWAS-identified risk loci for Alzheimer's disease in Han Chinese populations, Mol Neurobiol, 2016, 53(1):379-390.

(11) Wang HZ^#, Bi R^#, Zhang DF, Li GD, Ma XH, Fang Y, Li T, Zhang C, Yao YG*. Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese, Mol Neurobiol, 2016, 53: 4883-92.

(12) Bi R, Zhang W, Yu D, Li X, Wang HZ, Hu QX, Zhang C, Lu W, Ni J, Fang Y, Li T, Yao YG*. Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimer's disease in Han Chinese, Neurobiol Aging, 2015, 36(3):1604 e7-16.

(13) Bi R, Zhao L, Zhang C, Lu W, Feng JQ, Wang Y, Ni J, Zhang J, Li GD, Hu QX, Wang D, Yao YG*, Li T*. No association of the LRRK2 genetic variants with Alzheimer's disease in Han Chinese individuals, Neurobiol Aging, 2014, 35(2):444 e5-9.

(14) Bi R, Zhang AM, Jia X, Zhang Q, Yao YG*. Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G>A and Leber hereditary optic neuropathy, Mol Vis, 2012, 18:3087-3094.

(15) Bi R, Zhang AM, Yao YG*. Leber's hereditary optic neuropathy, Ophthalmology, 2011, 118(7):1489-1489 e1481.

(16) Bi R^#, Li WL^#, Chen MQ, Zhu Z, Yao YG*. Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny, Mutat Res, 2011, 709-710:15-20.

(17) Bi R, Zhang AM, Zhang W, Kong QP, Wu BL, Yang XH, Wang D, Zou Y, Zhang YP, Yao YG*. The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells, Hum Mutat, 2010, 31(5):538-543.

(18) Bi R, Zhang AM, Yu D, Chen D, Yao YG*. Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR, Clin Chim Acta, 2010, 411(21-22):1671-1674.

(19) Li C, Bi R, Wang L, Ma Y-H, Yao Y-G*, Zheng P*. Characterization of long-term ex vivo expansion of tree shrew spermatogonial stem cells. Zoological Research, 2023, 44(6): 1080-1094.

(20) Li C-H, Yan L-Z, Ban W-Z, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma Y-H, Nie W-H, Lv L-B, Yao Y-G*, Zhao X-D*, Zheng P*. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring, Cell Res, 2017, 27: 241-252.